Motif ID: SOX{8,9,10}.p2

Z-value: 1.093


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SOX9hg19_v1_chr17_+_70117154_701171640.431.5e-02Click!
SOX8hg19_v1_chr16_+_1032063_10320850.173.4e-01Click!
SOX10hg19_v1_chr22_-_38380538_383805690.173.6e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_46904879 4.632 NM_000258
MYL3
myosin, light chain 3, alkali; ventricular, skeletal, slow
chr1_+_156589085 3.228 NM_021817
HAPLN2
hyaluronan and proteoglycan link protein 2
chr2_-_158182154 2.879 NM_020711
ERMN
ermin, ERM-like protein
chr3_-_185826748 2.490 NM_004454
ETV5
ets variant 5
chr19_-_49658645 2.417 NM_002152
HRC
histidine rich calcium binding protein
chr6_-_46293215 2.341 RCAN2
regulator of calcineurin 2
chrX_+_49126326 2.148 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr1_-_205912546 2.090 NM_052934
NM_134325
SLC26A9

solute carrier family 26, member 9

chr6_-_46293404 1.925 RCAN2
regulator of calcineurin 2
chr14_-_102975996 1.871 ANKRD9
ankyrin repeat domain 9
chr8_-_70745403 1.849 NM_001146009
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr10_-_15130773 1.723 NM_001039844
ACBD7
acyl-CoA binding domain containing 7
chr4_-_186732047 1.706 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr11_-_35440514 1.697 SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_-_139613114 1.671 NM_153235
TXLNB
taxilin beta
chr14_-_102976096 1.645 NM_152326
ANKRD9
ankyrin repeat domain 9
chr10_-_97321094 1.590 NM_015385
NM_024991
SORBS1

sorbin and SH3 domain containing 1

chr4_+_41614911 1.556 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr8_+_144295067 1.514 NM_178172
GPIHBP1
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr5_-_83680191 1.504 EDIL3
EGF-like repeats and discoidin I-like domains 3
chr16_+_6069094 1.464 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr16_+_82660641 1.463 CDH13
cadherin 13, H-cadherin (heart)
chr19_-_47551881 1.447 NM_017854
TMEM160
transmembrane protein 160
chr16_-_46782104 1.430 NM_182493
MYLK3
myosin light chain kinase 3
chr1_-_160039946 1.422 NM_002241
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr4_+_41614933 1.404 LIMCH1
LIM and calponin homology domains 1
chr4_-_186732208 1.394 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr1_-_117210301 1.387 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr2_-_175629140 1.369 NM_000079
NM_001039523
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr9_+_27109138 1.368 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr14_-_103989112 1.356 CKB
creatine kinase, brain
chr16_+_82660573 1.354 CDH13
cadherin 13, H-cadherin (heart)
chr5_-_83680590 1.350 NM_005711
EDIL3
EGF-like repeats and discoidin I-like domains 3
chr12_-_8815266 1.349 MFAP5
microfibrillar associated protein 5
chr19_+_3880617 1.344 NM_033064
ATCAY
ataxia, cerebellar, Cayman type
chr12_-_6233684 1.298 NM_000552
VWF
von Willebrand factor
chr5_-_78809658 1.297 NM_004272
HOMER1
homer homolog 1 (Drosophila)
chr21_+_34398210 1.291 NM_005806
OLIG2
oligodendrocyte lineage transcription factor 2
chr10_-_75410778 1.258 NM_024875
SYNPO2L
synaptopodin 2-like
chr4_+_41614725 1.254 LIMCH1
LIM and calponin homology domains 1
chr7_+_107301079 1.250 NM_000441
SLC26A4
solute carrier family 26, member 4
chr17_-_37764165 1.247 NM_006160
NEUROD2
neurogenic differentiation 2
chr6_-_29644930 1.246 NM_001109809
ZFP57
zinc finger protein 57 homolog (mouse)
chr14_-_38725539 1.244 NM_175060
CLEC14A
C-type lectin domain family 14, member A
chr19_+_36359346 1.241 NM_001024807
NM_005166
APLP1

amyloid beta (A4) precursor-like protein 1

chr22_-_19512859 1.239 NM_001130861
NM_003277
CLDN5

claudin 5

chr16_+_82660390 1.234 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr1_-_24438625 1.233 NM_152372
MYOM3
myomesin family, member 3
chrX_-_45060081 1.221 NM_024689
NM_176819
CXorf36

chromosome X open reading frame 36

chr11_+_20049128 1.209 NAV2
neuron navigator 2
chr8_-_70745624 1.183 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr15_+_80696569 1.172 NM_014862
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr18_+_7946885 1.171 PTPRM
protein tyrosine phosphatase, receptor type, M
chr17_-_37353731 1.171 NM_000723
NM_199247
NM_199248
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr7_+_107110501 1.170 NM_005295
GPR22
G protein-coupled receptor 22
chr14_-_103989195 1.158 NM_001823
CKB
creatine kinase, brain
chrX_+_49126299 1.149 NM_001184745
NM_033215
PPP1R3F

protein phosphatase 1, regulatory subunit 3F

chr4_+_120056938 1.136 NM_016599
MYOZ2
myozenin 2
chr3_-_149051258 1.136 NM_001184723
NM_138786
TM4SF18

transmembrane 4 L six family member 18

chr4_-_101439071 1.126 NM_001159694
NM_016242
EMCN

endomucin

chr13_+_113656076 1.101 MCF2L
MCF.2 cell line derived transforming sequence-like
chr20_+_30193083 1.100 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr12_-_11548485 1.097 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr7_-_83270746 1.096 NM_001178129
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr10_+_24498088 1.093 KIAA1217
KIAA1217
chrX_+_82763268 1.093 NM_000307
POU3F4
POU class 3 homeobox 4
chr7_-_111846192 1.091 DOCK4
dedicator of cytokinesis 4
chr4_+_41540320 1.085 LIMCH1
LIM and calponin homology domains 1
chr17_-_73505914 1.081 NM_001142643
CASKIN2
CASK interacting protein 2
chr19_-_17375522 1.072 NM_031941
USHBP1
Usher syndrome 1C binding protein 1
chr14_+_91580713 1.072 C14orf159
chromosome 14 open reading frame 159
chr22_+_33197678 1.064 TIMP3
TIMP metallopeptidase inhibitor 3
chr14_-_38725253 1.060 CLEC14A
C-type lectin domain family 14, member A
chr11_+_131781303 1.056 NTM
neurotrimin
chr11_-_57417247 1.054 NM_145008
YPEL4
yippee-like 4 (Drosophila)
chr1_-_217311095 1.052 NM_001134285
ESRRG
estrogen-related receptor gamma
chr18_-_74729049 1.050 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr10_-_13749622 1.033 FRMD4A
FERM domain containing 4A
chr6_+_17282931 1.032 NM_153020
RBM24
RNA binding motif protein 24
chr17_+_46970128 1.032 NM_001002027
NM_005175
ATP5G1

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)

chr12_-_11508509 1.030 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr12_+_12938540 1.029 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr16_-_54319966 1.028 IRX3
iroquois homeobox 3
chr3_-_149688886 1.026 PFN2
profilin 2
chr2_-_56412904 1.013 LOC100129434
uncharacterized LOC100129434
chr5_-_16936371 1.009 NM_012334
MYO10
myosin X
chr5_+_140739589 1.008 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr16_+_66400524 1.003 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr10_+_73723992 1.003 NM_004273
CHST3
carbohydrate (chondroitin 6) sulfotransferase 3
chr16_+_66400585 0.988 CDH5
cadherin 5, type 2 (vascular endothelium)
chr9_+_124461365 0.974 DAB2IP
DAB2 interacting protein
chr3_+_111717585 0.970 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr19_+_3880675 0.965 ATCAY
ataxia, cerebellar, Cayman type
chr19_+_3880660 0.963 ATCAY
ataxia, cerebellar, Cayman type
chr6_-_76203256 0.956 NM_015687
FILIP1
filamin A interacting protein 1
chr22_+_33197744 0.955 TIMP3
TIMP metallopeptidase inhibitor 3
chr3_+_147111221 0.953


chr1_+_203096835 0.950 NM_000674
NM_001048230
ADORA1

adenosine A1 receptor

chr3_+_181417387 0.946 SOX2-OT
SOX2 overlapping transcript (non-protein coding)
chrX_+_49126480 0.944 PPP1R3F
protein phosphatase 1, regulatory subunit 3F
chr3_+_39509069 0.942 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_-_72130447 0.930 LINC00472
long intergenic non-protein coding RNA 472
chr18_-_74728963 0.927 MBP
myelin basic protein
chr14_+_91580467 0.924 C14orf159
chromosome 14 open reading frame 159
chr13_-_33760215 0.923 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr12_-_8815370 0.922 NM_003480
MFAP5
microfibrillar associated protein 5
chr17_+_40119669 0.922


chr10_+_24497719 0.921 NM_001098501
NM_019590
KIAA1217

KIAA1217

chr3_+_111718006 0.909 NM_001008273
TAGLN3
transgelin 3
chr6_+_123100860 0.905 FABP7
fatty acid binding protein 7, brain
chr14_+_91580967 0.895 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr4_-_5890142 0.893 CRMP1
collapsin response mediator protein 1
chr1_-_169455099 0.887 NM_006996
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr2_+_220309373 0.886 SPEG
SPEG complex locus
chr17_+_36584692 0.883 NM_001199417
ARHGAP23
Rho GTPase activating protein 23
chrX_+_65384078 0.881 NM_001130860
NM_014799
HEPH

hephaestin

chr2_+_153191830 0.878 FMNL2
formin-like 2
chr7_-_131241321 0.868 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr15_+_71184781 0.866 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr12_+_53443834 0.865 NM_170754
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr6_+_17282294 0.860 NM_001143941
RBM24
RNA binding motif protein 24
chr9_+_2622134 0.860 VLDLR
very low density lipoprotein receptor
chr11_+_131780537 0.857 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr16_+_66400559 0.856 CDH5
cadherin 5, type 2 (vascular endothelium)
chr21_+_41239346 0.855 NM_006198
PCP4
Purkinje cell protein 4
chr12_-_18243052 0.855 NM_024730
RERGL
RERG/RAS-like
chr7_-_44887663 0.854 H2AFV
H2A histone family, member V
chr2_+_198669316 0.854 NM_006226
PLCL1
phospholipase C-like 1
chr8_+_21924369 0.853 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr17_+_8213555 0.853 NM_173728
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr15_+_82944821 0.842 AGSK1
golgin subfamily A member 2-like
chr10_+_24755459 0.842 KIAA1217
KIAA1217
chr15_+_82944772 0.834 AGSK1
golgin subfamily A member 2-like
chr2_+_159313407 0.834 PKP4
plakophilin 4
chr17_-_38210611 0.832 MED24
mediator complex subunit 24
chr12_-_11002051 0.832 NM_001098538
NM_007244
PRR4

proline rich 4 (lacrimal)

chr1_-_27701302 0.832 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr19_-_55660557 0.830 NM_001126132
NM_001126133
NM_003283
TNNT1


troponin T type 1 (skeletal, slow)


chr6_-_110736748 0.823 NM_003649
NM_004032
DDO

D-aspartate oxidase

chr1_+_26503973 0.818 NM_006314
CNKSR1
connector enhancer of kinase suppressor of Ras 1
chr10_+_6244839 0.817 NM_004566
PFKFB3
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr8_+_40010986 0.814 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr5_+_140593508 0.805 NM_018933
PCDHB13
protocadherin beta 13
chr1_-_85930610 0.803 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr4_-_177190258 0.798 NM_080874
ASB5
ankyrin repeat and SOCS box containing 5
chr20_+_58179601 0.797 NM_080672
PHACTR3
phosphatase and actin regulator 3
chr5_-_41510627 0.794 NM_001005473
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_-_149858114 0.790 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr1_-_186417855 0.789 NM_022576
PDC
phosducin
chr1_-_79472360 0.789 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr15_-_83876769 0.785 HDGFRP3
hepatoma-derived growth factor, related protein 3
chr2_-_45236521 0.782 NM_016932
SIX2
SIX homeobox 2
chr14_+_91580356 0.781 NM_001102366
NM_001102368
NM_001102369
NM_024952
C14orf159



chromosome 14 open reading frame 159



chr17_-_55980749 0.780 NM_017949
CUEDC1
CUE domain containing 1
chr9_+_2622099 0.780 VLDLR
very low density lipoprotein receptor
chr5_-_146833150 0.778 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr3_-_62860561 0.778


chr5_+_140602914 0.774 NM_018934
PCDHB14
protocadherin beta 14
chr14_-_94442894 0.774 ASB2
ankyrin repeat and SOCS box containing 2
chr9_+_132934685 0.773 NM_014286
NCS1
neuronal calcium sensor 1
chr9_-_14398981 0.772 NM_001190738
NFIB
nuclear factor I/B
chr6_+_121756744 0.768 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr20_+_61147924 0.767 C20orf166
chromosome 20 open reading frame 166
chr2_-_175869910 0.764 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr4_+_115543522 0.762 NM_003360
UGT8
UDP glycosyltransferase 8
chrY_-_21239250 0.760 TTTY14
testis-specific transcript, Y-linked 14 (non-protein coding)
chr16_+_2083264 0.760 NM_001252073
NM_001252075
NM_001252076
SLC9A3R2


solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2


chr4_+_184827882 0.757


chr5_+_140797210 0.755 NM_032101
PCDHGB7
protocadherin gamma subfamily B, 7
chr6_+_123100645 0.748 NM_001446
FABP7
fatty acid binding protein 7, brain
chrX_+_152954965 0.745 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr4_+_184827805 0.745 STOX2
storkhead box 2
chr2_-_161056762 0.744 ITGB6
integrin, beta 6
chr10_-_98119058 0.736 NM_001040102
NM_001040103
NM_033207
OPALIN


oligodendrocytic myelin paranodal and inner loop protein


chr14_+_63671101 0.721 NM_020663
RHOJ
ras homolog gene family, member J
chr12_-_88974094 0.720 NM_000899
NM_003994
KITLG

KIT ligand

chr16_+_58534045 0.716 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr8_-_82395401 0.711 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr2_-_151344145 0.708 NM_005168
RND3
Rho family GTPase 3
chr18_+_55711388 0.705 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr14_+_55168831 0.702 SAMD4A
sterile alpha motif domain containing 4A
chrX_-_13835313 0.699 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr12_-_71003622 0.694 NM_001206971
NM_001206972
NM_002837
PTPRB


protein tyrosine phosphatase, receptor type, B


chr7_-_111846384 0.689 NM_014705
DOCK4
dedicator of cytokinesis 4
chr1_+_47489239 0.688 NM_178033
CYP4X1
cytochrome P450, family 4, subfamily X, polypeptide 1
chr4_+_41540187 0.688 LIMCH1
LIM and calponin homology domains 1
chr5_+_149980627 0.687 NM_001166208
SYNPO
synaptopodin
chr17_+_44928947 0.687 NM_003396
WNT9B
wingless-type MMTV integration site family, member 9B
chr16_-_75285383 0.685 NM_001170717
NM_014567
BCAR1

breast cancer anti-estrogen resistance 1

chr5_+_180467224 0.683 NM_152547
BTNL9
butyrophilin-like 9
chr6_-_11232900 0.683 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr4_+_183245136 0.682 NM_001080477
ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr2_-_170218972 0.680 LRP2
low density lipoprotein receptor-related protein 2
chr3_-_9439122 0.679 LOC440944
uncharacterized LOC440944
chr2_-_55277672 0.678 RTN4
reticulon 4
chr10_+_70748476 0.677 NM_015634
KIAA1279
KIAA1279
chr14_-_93214873 0.675 NM_001008530
NM_005606
LGMN

legumain

chr15_-_93277303 0.674 FAM174B
family with sequence similarity 174, member B
chr7_-_117513466 0.671 CTTNBP2
cortactin binding protein 2
chr22_-_36013303 0.671 NM_005368
NM_203378
MB

myoglobin


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.47 1.04e-03 GO:0048731 system development
2.25 1.46e-03 GO:0007275 multicellular organismal development
2.30 2.54e-03 GO:0048856 anatomical structure development
2.12 3.38e-03 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
19.29 4.79e-03 GO:0031674 I band

Nothing significant found in function category.